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Description
Alexa Fluor 647-Labeled CD38 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms ADPRC1,cADPR1,ADPRC 1 Accession P28907 1 Amino Acid Sequence Val43 Ile300 with Human IgG1 Fc at C terminal Expression System HEK293 Molecular Weight 68 72kDa (Reducing) Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile conditions after reconstitution. 1
Product Specification
| Species | Human |
| Synonyms | ADPRC1,cADPR1,ADPRC 1 |
| Accession | P28907-1 |
| Amino Acid Sequence | Val43-Ile300 with Human IgG1 Fc at C-terminal |
| Expression System | HEK293 |
| Molecular Weight | 68-72kDa (Reducing) |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Matas-Céspedes A, Vidal-Crespo A, Rodriguez V, Villamor N, Delgado J, Giné E, Roca-Ho H, Menéndez P, Campo E, López-Guillermo A, Colomer D, Roué G, Wiestner A, Parren PW, Doshi P, van Bueren JL, Pérez-Galán P. The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 Mar 15;23(6):1493-1505. |
Background
Daratumumab is a first-in-class Homo sapiens monoclonal antibody of the IgG1 class, specifically targeting the human CD38 protein. It binds to CD38, triggering apoptosis via mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). This antibody is applicable for research related to hematoma, suitable for use in both human and immunodeficient mouse models. Studies have indicated that Daratumumab also exerts influence on the survivability and transmission of chronic lymphocytic leukemia (CLL), particularly in cases characterized by poor prognosis and high CD38 expression.
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